Whats the difference between RRF and Impurity RRF
Both RRF and Impurity RRF appear in the components tab, what is the difference exactly?
There's quite a few "Tip of the week" entries around impurity processing:
The latest, #78, has a little info on the difference...basically compare step 1 and step 2. My interpretation of this is that the typical "RRF" is really for when you want to specify the curve reference (maybe you have 2 APIs and are saying API1_Deg uses API1 whereas API2_Deg uses API2 for curve references). The "Impurity RRF" allows the user to simplify by assigning a single, default peak instead which means you don't need to add every integrated peak to the component table.
Ultimately, there doesn't seem to be any other practical difference.
RRF or RRT ?
RRF for relative response factor
Relative Response Factor (RRF) is an analytical parameter used in chromatographic procedures to control impurities/degradants in drug substance and drug product.
RRF is used to correct the difference in detector response of impurities with analyte peak.
Calculation of RRF:
Relative Response Factor (RRF) = Response Factor A / Response Factor B
Response Factor = Peak Area / Concentration