Hello, can we sonicate Solvent bottle filter? what chemicals we can use?

JosphinJosphin
in ACQUITY UPLC/UHPLC
Retention time is increasing 

Answers

  • MarcNobleMarcNoble
    Hard to say if late RT is being caused by solvent flow, but we find the best all purpose cleaning solution for most LC parts is - 25:25:25:25 IPA/ACN/MeOH/H2O with 0.2% formic acid (v/v).

    You can also reference the Controlling contamination guide

    Hope this helps!
    Marc 
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