Hello, can we sonicate Solvent bottle filter? what chemicals we can use?
Retention time is increasing
Hard to say if late RT is being caused by solvent flow, but we find the best all purpose cleaning solution for most LC parts is - 25:25:25:25 IPA/ACN/MeOH/H2O with 0.2% formic acid (v/v).
You can also reference the
Controlling contamination guide
Hope this helps!