Acetone for TQD

I'm working on ephedrines and amphetamines in HILIC mode using TQD system and investigating BEH HILIC, BEH Amide and ZIC-HILIC columns for rapid and sensitive results.Can anyone suggest me that the sensitive and resolution will have increased or not ? if i try Acetone or acetone/acetonitrile (50/50) in place of acetonitrilethanks
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