carry-over problems

Dear all,I use for the Dextrorphan determination an Acqiity UPLC System (binery pump) connected with an API 5500 Qtrap.Unfortunately I have carry-over problems. About 10% is the carry-over from sample to sample.In my UPLC-method I use a "Partial Loop With Needle Overfill"-injection mode. Further I use these Wash Solvents:Weak: 100% ACNStrong + Seal Wash: 0.1%FA/ACN (90%/10%)What can I do to minimize this problem?Kind regards,Simone
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