Empower custom calculation

<p>Hi, </p><p></p><p>We have one new impurity method for tablet having two active ingredient. </p><p>Routine we have been calculating impurities using Empower custom fields and custom calculation. However in this case it is single method using dual wavelength detector (We use UPLC with PDA detector) . </p><p></p><p>My question is how to calculate the % impurities using Empower custom fields calculation and using single processing method set. </p><p></p><p>Few more information :</p><p></p><p>Impurities are calculated w.r.t diluted solution of two active ingredient.</p><p></p><p>Active ingredient 1: RT about 8 minutes and </p><p></p><p>Active ingredient 2: RT about 12 minutes</p><p></p><p>There are about 20 impurities and out of 20, 5 are related impurities/degradant of active 1 and other fifteen are of active 2.</p><p></p><p>If any one is having past experience, please share.</p><p></p><p>Regards</p><p></p><p>Raju</p>


  • lizh


    Our first thought is not a custom field. If they want to do this by calibrating some imp peaks against the first main peak and some against the second, that can be done in the processing method. Using dual wavelengths will cause additional complications either through native processing or using custom field. This type of calculations is used in MassSpec.

    Does this sound like an approach?

    It might be a good idea to conta t your local data specialist through your sales representative, or iRequest.

    Let us know


  • You can use the curve reference field in the processing method component window to have a component (impurity) use the calibration from another component (active ingredient).

    You can also specify channel for any given component in the component as well so you can calibrate at one wavelength for the standard and another for the impurities.

  • lizh

    The link to the Guide on calculations should assist.