Sirocco Plate

<p><span>I know that my question is not strictly related to the community, but I'm setting up an UPLC method to perform solubility screening for discovery compounds.</span></p><p><span>I'd like to use Sirocco Plates but I'd like to know which is the mesh of the membrane.</span></p><p><span>Colud some one help me ?</span></p><p><span>Thanks,</span></p><p><span>Marco</span></p>


  • dougm

    Hello. The Sirocco Plate has a stack of membranes and a filter. The bigger mesh sizes are in the 1 micron range. These act like a 'screen', keeping much of the precipitate away from the surface of the filter and plugging it. The Sirocco Plate acts as a 0.45 micron filter. We tested both 0.22 micron and 0.45 micron porosities during the development of the product. We felt that the flow characteristics with 0.45 micron porosity were much better.

    I hope this information helps.


  • Thank you very much.