Can I determine the concentration of acetonitrile with UPLC???

I need you help. Can I determine the concentration of acetonitrile with UPLC or HPLC???Thank you

Answers

  • My initial thought when I first read this question was no, you cant do this and obviously, GC would be a much better choice for this kind of assay. That being said I hesitate to say that ther is no way it can be done. After thinking about it I can come up with detection choices (RI maybe and CLND) but I have yet to think of any way to seperate the ACN from what ever other sample components there may be.

  • If you only have TUV or PDA detector, the test would be difficult, but it can be done if you have MS detector.

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