Acetonitrile Shortage? If so what strategies are being adopted?
In conversations with users I am hearing about the continuing shortage of acetonitrile and that it is predicted to extend through 2009. Initially at Waters, we had heard from customers that their orders would be partially filled and they might expect a reduced supply, but more recently we are hearing that orders are being drastically cut. Is this the case? What is your company doing to alleviate the shortage and redistribute what supplies they have to critical applications?At Waters we have discussing possible solutions. It is not easy to take a method that uses ACN to substitute methanol and expect the same selectivity, but scaling down column ID does offer a way to reduce solvent consumption dramatically without compromising the separation. With ACQUITY UPLC the use of 2.1 mm column ID's will reduce solvent usage and even existing 2.1 mm UPLC methods can be scaled to 1 mm column ID's.There are of course implications for any method is change, however small. Are any of your Scientific Affairs personnel contacting Regulatory bodies to ask questions about similar strategies. And what else should Waters be doing to help?