Room temperature influences peak shape. Heat emission data?
Hello,during summer we noticed the influence of the room temperature (as well as humidity) on our LC-MS/MS systems, especially the MS part. Here we could see shifts in the m/z of our analytes which resulted in very low peak heights. Unfortunately we are a university hospital and the results of our methods directly influence the treatment of our patients. As a consequence, we daily had to tune our analytes to correct the masses. I don't have to tell you that this is very time consuming and impractical. We had several Waters technicians to work on this problem but no one 1. ever heard of this problem and 2. could help us. Does anybody has similar problems?We bought a second air conditioning device and somewhat could minimize the problem. However, this device will have to be replaced with a new climate control unit because it consumes to much lab space. Are there any data on the heat emission of the LC-MS/MS systems?Our LC-MS/MS systems:- Acquity UPLC - Quattro Premier XE with an Edwards E2M28 vacuum pump- Waters Alliance 2795 - Quatro Micro API with an Edwards E2M28 vacuum pumpThank you very much for your help!Susan