Polyethylene Glycol samples on the UPLC

Karen · April 2010

We have several HPLC assays that either have PEG (polyethylene glycol) as the sample, or a component of the sample. Is it ok to run these samples with the UPLC/MS? I thought I heard in training once that PEG would build up in the system. Does anyone have experience with PEG on the UPLC? Any advice is helpful!-Karen Birdwell

lizh · April 2010

Karen

The answer is yes, PEGs are usually avoided in MS, they are sources of contamination. There are alraedy some good posts on this subject. I just did a quick serach to bring up them up... searching on "glycol". Here is the link.

http://forums.waters.com/clearspace_community/search.jspa?resultTypes=BLOG_POST&resultTypes=DOCUMENT&resultTypes=MESSAGE&resultTypes=BLOG&resultTypes=COMMUNITY&resultTypes=TASK&resultTypes=PROJECT&resultTypes=COMMENT&peopleEnabled=true&q=glycol

Best regards,

Liz

Polyethylene Glycol samples on the UPLC

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