Spikes in chromatogram with Agilent 1260 Infinity II, run from LACE with ICF 2.2

Why do I see spikes in chromatograms and communication errors on Agilent 1260 Infinity II using Empower directly controlled by LACE with ICF 2.2? Do we need to use ICF 2.1, hot fix 1 on LACE, or can we use ICF 2.2? Understand ICF 2.2 can be loaded on workstation (Client server) for Agilent 1260 Infinity II, but not sure if this is the case if using LACE to directly control the HPLC. 


  • We have a similar setup in our Empower deployment and I do not observe spikes in chromatograms.

    If you have ICF Support 2.2 installed, then what version of ICF are you running? A.02.04?

  • Our IT is handling it now and it is a little complicated because we need to upgrade to ICF 3.0 to get ICS 2.2.
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